Welcome to the laboratory of Saurabh Sinha at the University of Illinois, Urbana-Champaign.
Our research focuses on computational approaches to problems in molecular biology. In particular, we are interested in exploring gene regulation, mostly in metazoan genomes. We approach the subject through an integrated analysis of DNA sequence and gene expression data. We also strive to understand how sequences involved in gene regulation have evolved, and how such evolutionary dynamics may inform the discovery of novel regulatory sequences. Broadly speaking, our work falls in the areas of regulatory and comparative genomics.
Principal Investigator: Saurabh Sinha.
POST-DOC POSITION AVAILABLE: See here.
FEATURED NEW RESEARCH: Two papers describing TF interactions by modeling ChIP data or by sequence analysis
Q. Cheng, M. Kazemian, H. Pham, C. Blatti, S. E. Celniker, S. A. Wolfe, M. H. Brodsky, S. Sinha (2013). Computational identification of diverse mechanisms underlying transcription factor-DNA occupancy. PLoS Genetics. 2013 Aug;9(8):e1003571. [Free Full Text] Voted one of Top 10 papers of 2012-13 in Regulatory Genomics !
M. Kazemian, H. Pham, S.A. Wolfe, M.H. Brodsky, S. Sinha (2013). Widespread evidence of cooperative DNA-binding by transcription factors in Drosophila development. Nucleic Acids Research. 2013 Jul 11. PMID: 23847101. [Free Full Text]
FEATURED NEW RESEARCH: Framework to model the evolution of regulatory sequences
Thyago Duque, Md. Abul Hassan Samee, Majid Kazemian, Hannah N. Pham, Michael H. Brodsky, Saurabh Sinha (2013). Simulations of enhancer evolution provide mechanistic insights into gene regulation. MBE 2013; doi: 10.1093/molbev/mst170 [Advanced Access Text]