Welcome to the laboratory of Saurabh Sinha at the University of Illinois, Urbana-Champaign.
Our research focuses on computational approaches to problems in molecular biology. In particular, we are interested in exploring gene regulation, mostly in metazoan genomes. We approach the subject through an integrated analysis of DNA sequence, gene expression, and epigenetic data. We also strive to understand how sequences involved in gene regulation have evolved, and how such evolutionary dynamics may inform the discovery of novel regulatory sequences. Broadly speaking, our work falls in the areas of regulatory and comparative genomics.
Principal Investigator: Saurabh Sinha.
FEATURED RECENT RESEARCH:
How to really understand how an enhancer works?
M.A.H. Samee, B. Lim, N. Samper, H. Lu, C.A. Rushlow, G. Jiménez, S.Y. Shvartsman, S. Sinha (2015) "A Systematic Ensemble Approach to Thermodynamic Modeling of Gene Expression from Sequence Data", Cell Systems, 1(6):396-407. [Full text]. Previewed by Dresch & Arnosti.
Why does drug response vary from one individual to another?
C. Hanson, J. Cairns, L. Wang, S. Sinha (2015). "Computational discovery of transcription factors associated with drug response", The pharmacogenomics journal. [Free full text]
How "big" is genomics going to get?
Z. D. Stephens, S. Y. Lee, F. Faghri, R. H. Campbell, C. Zhai, M. J. Efron, R. Iyer, M. C. Schatz*, S. Sinha*, G. E. Robinson* (2015). *Co-corresponding authors. "Big Data: Astronomical or Genomical?", PLoS Biology, 13(7):e1002195. [Free full text]