ASBMB - Evolution and Core Processes in Gene Regulation

Simulations of enhancer evolution provide mechanistic insights into gene regulation


by Thyago Duque, Md. Abul Hassan Samee, Majid Kazemian, Hannah N. Pham, Michael H. Brodsky, Saurabh Sinha

contact: Thyago Duque (tduque2) or Saurabh Sinha (sinhas) (@illinois.edu) 

Updated poster available here.

For more information visit Sinha Laboratory main page.

References:

Duque, T.S., Samee M. A. H., Kazemian, M., Pham, H., Brodsky, M. H., Sinha, S. (2013) Simulations of enhancer evolution provide mechanistic insights into gene regulation. In review. 

He, X., Duque, T. S., & Sinha, S. (2012). Evolutionary origins of transcription factor binding site clusters. Molecular biology and evolution, 29(3), 1059-1070.

He, X., Samee, M. A. H., Blatti, C., & Sinha, S. (2010). Thermodynamics-based models of transcriptional regulation by enhancers: the roles of synergistic activation, cooperative binding and short-range repression. PLoS computational biology, 6(9), e1000935.

Kim, J., He, X., & Sinha, S. (2009). Evolution of regulatory sequences in 12 Drosophila species. PLoS genetics, 5(1), e1000330.