About Us

Welcome to the laboratory of Saurabh Sinha at the University of Illinois, Urbana-Champaign.

Our research focuses on computational approaches to problems in molecular biology. In particular, we are interested in exploring gene regulation, mostly in metazoan genomes, in the biological contexts of development, behavior and cancer. We approach the subject through an integrated analysis of DNA sequence, gene expression, and epigenetic data. We also strive to understand how sequences involved in gene regulation have evolved. Broadly speaking, our work falls in the areas of regulatory and comparative genomics.

Principal Investigator: Saurabh Sinha.


FEATURED RECENT RESEARCH:

A Cloud-based knowledge engine for genomics

C. Blatti, A. Emad, M.J. Berry, ... C.B. Bushell, S. Sinha (2019). Knowledge-guided analysis of ‘omics’ data using the KnowEnG cloud platform. To appear in PLoS Biology. [Preprint]

Robot uses Bayesian optimization to plan experiments without human intervention

M HamediRad, R Chao, S Weisberg, J Lian, S Sinha, H Zhao (2019). Towards a fully automated algorithm driven platform for biosystems design. Nature communications, 10 (1), 1-10. [Free full text]

Graphical models help identify major transcriptional regulators of drug response variation

Hanson, C., Cairns, J., Wang, L., & Sinha, S. (2018). Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation. Genome Res, 28(8), 1207-1216. [Free full text]